High dose vitamin C (HDVC)

Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold

An article in the Journal of the American Academy of Nurse Practitioners presents a critical evaluation of the current evidence concerning the therapeutic value of vitamin C for the prophylaxis and treatment of the common cold.

Heimer, K. A., Hart, A. M., Martin, L. G., & Rubio-Wallace, S. (2009). Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold. Journal of the American Academy of Nurse Practitioners, 21(5), 295–300. https://doi.org/10.1111/j.1745-7599.2009.00409.x (https://pubmed.ncbi.nlm.nih.gov/19432914/)

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

A review in the Journal of experimental & clinical cancer research provides an elaborate overview of pre-clinical and clinical studies using high-dose IVC as anti-cancer agent, as well as a detailed evaluation of the main known molecular mechanisms involved. In addition, an outlook on future implications of high-dose vitamin C in cancer treatment is presented and recommendations for further research are discussed.

Böttger, F., Vallés-Martí, A., Cahn, L., & Jimenez, C. R. (2021). High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. Journal of experimental & clinical cancer research : CR, 40(1), 343. https://doi.org/10.1186/s13046-021-02134-y (https://pubmed.ncbi.nlm.nih.gov/34717701/)

High-dose vitamin C enhances cancer immunotherapy

A study in Science translational medicine shows that a fully competent immune system is required to maximize the antiproliferative effect of VitC in breast, colorectal, melanoma, and pancreatic murine tumors. High-dose VitC modulates infiltration of the tumor microenvironment by cells of the immune system and delays cancer growth in a T cell-dependent manner.

Magrì, A., Germano, G., Lorenzato, A., Lamba, S., Chilà, R., Montone, M., Amodio, V., Ceruti, T., Sassi, F., Arena, S., Abrignani, S., D'Incalci, M., Zucchetti, M., Di Nicolantonio, F., & Bardelli, A. (2020). High-dose vitamin C enhances cancer immunotherapy. Science translational medicine, 12(532), eaay8707. https://doi.org/10.1126/scitranslmed.aay8707 (https://pubmed.ncbi.nlm.nih.gov/32102933/)

Intravenously administered vitamin C as cancer therapy: three cases

A case report in the Canadian Medical Association journal = journal de l'Association medicale canadienne found 3 well-documented cases of advanced cancers, confirmed by histopathologic review, where patients had unexpectedly long survival times after receiving high-dose intravenous vitamin C therapy. The report examines clinical details of each case in accordance with National Cancer Institute (NCI) Best Case Series guidelines.

Padayatty, S. J., Riordan, H. D., Hewitt, S. M., Katz, A., Hoffer, L. J., & Levine, M. (2006). Intravenously administered vitamin C as cancer therapy: three cases. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 174(7), 937–942. https://doi.org/10.1503/cmaj.050346 (https://pubmed.ncbi.nlm.nih.gov/16567755/)